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Category: Computer Engineering

Molecular Motor Proteins » Curious Cat Science and Engineering Blog

Molecular Motor Proteins Posted on January 27, 2020  Comments (0) Webcast on amazing processes inside cells by Ron Vale. Molecular motor proteins are fascinating enzymes that power much of the movement performed by living organisms. The webcast provides an overview of the motors that move along cytoskeletal tracks (kinesin and dynein which move along microtubules and myosin which moves along actin). The talk first describes the broad spectrum of biological roles that kinesin, dynein and myosin play in cells. The…

JavaScript Libraries Are Almost Never Updated Once Installed

Cloudflare helps run CDNJS, a very popular way of including JavaScript and other frontend resources on web pages. With the CDNJS team’s permission we collect anonymized and aggregated data from CDNJS requests which we use to understand how people build on the Internet. Our analysis today is focused on one question: once installed on a site, do JavaScript libraries ever get updated? Let’s consider jQuery, the most popular JavaScript library on Earth. This chart shows the number of requests made…

Device could be used to find threats to ecosystems — ScienceDaily

Imagine a device that could swiftly analyze microbes in oceans and other aquatic environments, revealing the health of these organisms — too tiny to be seen by the naked eye — and their response to threats to their ecosystems. Rutgers researchers have created just such a tool, a portable device that could be used to assess microbes, screen for antibiotic-resistant bacteria and analyze algae that live in coral reefs. Their work is published in the journal Scientific Reports. The tool,…

Can lithium halt progression of Alzheimer’s disease? Researchers’ findings show that may be the case — ScienceDaily

There remains a controversy in scientific circles today regarding the value of lithium therapy in treating Alzheimer’s disease. Much of this stems from the fact that because the information gathered to date has been obtained using a multitude of differential approaches, conditions, formulations, timing and dosages of treatment, results are difficult to compare. In addition, continued treatments with high dosage of lithium render a number of serious adverse effects making this approach impracticable for long term treatments especially in the…

Opioid dependence found to permanently change brains of rats — ScienceDaily

Approximately one-quarter of patients who are prescribed opioids for chronic pain misuse them, with five to 10 percent developing an opioid use disorder or addiction. In a new study, published Jan. 14, 2020 in PNAS, researchers at University of California San Diego School of Medicine found that opioid dependence produced permanent changes in the brains of rats. More specifically, researchers reported that dependence on oxycodone, a potent opioid painkiller, led to permanent neuro-adaptations of the central nucleus of the amygdala…

Long understood as source of novel genetic traits, jumping genes also provide genomic stability — ScienceDaily

“Jumping genes” — bits of DNA that can move from one spot in the genome to another — are well-known for increasing genetic diversity over the long course of evolution. Now, new research at Washington University School of Medicine in St. Louis indicates that such genes, also called transposable elements, play another, more surprising role: stabilizing the 3D folding patterns of the DNA molecule inside the cell’s nucleus. The study appears Jan. 24 in the journal Genome Biology. The DNA…

Research underway to address latest viral threat — ScienceDaily

The new cluster of viral pneumonia cases originating in Wuhan, China, marks the third time in 20 years that a member of the large family of coronaviruses (CoVs) has jumped from animals to humans and sparked an outbreak. In a new JAMA Viewpoint essay, Anthony S. Fauci, M.D., director of the NIH’s National Institute of Allergy and Infectious Diseases (NIAID), looks back at two earlier novel CoV outbreaks that initially caused global havoc and describes steps needed to contain the…

Using graph algorithms to optimize Kafka operations, Part 1

Ping-Min Lin | Software Engineer, Logging Platform Pinterest uses Kafka across the board for data movement. The Logging Platform team alone manages over 3,000 Kafka brokers transporting trillions of messages per day to help bring more than 320 million monthly active Pinners the inspiration to create a life they love. The Logging Platform team has developed several tools to keep operations smooth in a deployment of this scale. In this post, we’ll share how we leverage graph algorithms to efficiently solve problems…

Designing a Production-Ready Kappa Architecture for Timely Data Stream Processing

At Uber, we use robust data processing systems such as Apache Flink and Apache Spark to power the streaming applications that helps us calculate up-to-date pricing, enhance driver dispatching, and fight fraud on our platform. Such solutions  can process data at a massive scale in real time with exactly-once semantics, and the emergence of these systems over the past several years has unlocked an industry-wide ability to write streaming data processing applications at low latencies, a functionality previously impossible to…

Android App Modularization at Wealthfront (Part 3) – Engineering Blog

In the previous blog post, we looked at how we started with modularization and refactored our existing code into the legacy module which was ready to be modularized into smaller infrastructure and feature modules. In this blog post, we will go in detail about how we’d refactored our infrastructure modules with the help of interfaces.  Phase 3 – Breaking out the infra modules The next part of the project was to break out the legacy module into smaller modules. The…